The main theme encompassing ‘The Run and Go’ is that Tyler feels as if he is a burden to an individual, likely God. Tyler recognizes he is a flawed individual and that he may be hard to deal with, so he expresses his concern for involving God in his personal problems.
Tyler has said that he wrote this song with concerts in mind. He wrote it to be a song that needs the crowd to be involved in. And they do a good job at making sure they do get involved. .