This song is a reflection of Dave Mustaine's former heroin addiction. The title is analogous to methadone, a narcotic often used in treating heroin addiction. In theory, doses of methadone will substitute those of heroin and can gradually be decreased until the patient is free of his addiction. Often, however, the patient's methadone addiction will simply replace his heroin addiction. Another interpretation is that when Dave first turned to drugs, his life was not going very well and he was looking for a cure. .

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